<!DOCTYPE html>
<html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-0 vector-toc-not-available vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-0 skin-theme-clientpref-day vector-sticky-header-enabled" lang="de" dir="ltr"><head>
<meta charset="UTF-8">
<title>MDA5</title>
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<link rel="icon" type="image/png" href="./_res_/favicon.png">
<link rel="canonical" href="https://de.wikipedia.org/wiki/MDA5"> <link href="./_mw_/ext.cite.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.wikimediamessages.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.icons.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.search.codex.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.styles.css" rel="stylesheet" type="text/css">
<meta name="ResourceLoaderDynamicStyles" content="">
<link href="./_mw_/ext.gadget.citeRef.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.defaultPlainlinks.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonHide.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonLayout.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonStyle.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiDarkmode.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiResponsive.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.specialSearch.css" rel="stylesheet" type="text/css">
<link rel="stylesheet" type="text/css" href="./_mw_/site.styles.css">
<link rel="stylesheet" type="text/css" href="./_mw_/noscript.css">
<link rel="stylesheet" type="text/css" href="./_res_/footer.css">
<link rel="stylesheet" type="text/css" href="./_res_/vector-2022.css">
</head>
<body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject page-MDA5 rootpage-MDA5 skin-vector-2022 action-view">
<div class="mw-page-container">
<div class="mw-page-container-inner">
<div class="mw-content-container">
<main id="content" class="mw-body">
<header class="mw-body-header vector-page-titlebar">
<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">MDA5</span></h1>
</header>
<a id="top"></a>
<div id="bodyContent" class="vector-body ve-init-mw-desktopArticleTarget-targetContainer" aria-labelledby="firstHeading" data-mw-ve-target-container="">
<div id="contentSub">
<div id="mw-content-subtitle"></div>
</div>
<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_MDA5" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
<tbody><tr>
<th colspan="3" style="background:#90EE90; color:#202122;">MDA5
</th></tr>
<tr style="text-align:center;">
<td colspan="3"><span typeof="mw:File"></span>
</td></tr>
<tr>
<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;">nach <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2RQB">2RQB</a>
</td></tr>
<tr>
<td>Andere Namen
</td>
<td colspan="2">
<p>IFIH1
</p>
</td></tr>
<tr>
<td colspan="3" class="hintergrundfarbe1" style="font-size:smaller;">
<p>Vorhandene Strukturdaten: <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2RQB">2RQB</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3B6E">3B6E</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3GA3">3GA3</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4GL2">4GL2</a></span>
</p>
</td></tr>
<tr>
<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
</th></tr>
<tr>
<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
</td>
<td colspan="2" style="text-align:center;">116,6 <a href="Atomare_Masseneinheit" title="Atomare Masseneinheit">Kilodalton</a> / 1.025 <a href="Aminos%C3%A4ure" class="mw-redirect" title="Aminosäure">Aminosäuren</a> (Isoform 1)
<p>25 Kilodalton 221 Aminosäuren (Isoform 2)
</p>
</td></tr>
<tr>
<td><a href="Isoform" title="Isoform">Isoformen</a>
</td>
<td colspan="2" style="text-align:center;">2
</td></tr>
<tr>
<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
</th></tr>
<tr>
<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Namen</a>
</td>
<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=18873">MDA5</a></i>, AGS7, Hlcd, IDDM19, MDA-5, RLR-2
</td></tr>
<tr>
<td>Externe IDs
</td>
<td colspan="2" class="">
<ul><li><a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=IFIH1">IFIH1</a></li>
<li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/606951">606951</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q9BYX4">Q9BYX4</a></li>
<li><a href="Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="https://www.informatics.jax.org/marker/MGI:1918836">1918836</a></li></ul>
</td></tr>
<tr>
<th colspan="3" style="background:#90EE90; color:#202122;">Enzymklassifikation
</th></tr>
<tr>
<td><a href="EC-Nummer" title="EC-Nummer">EC, Kategorie</a>
</td>
<td colspan="2" class="" style="text-align:center;"><a rel="nofollow" class="external text" href="https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.4.13">3.6.4.13</a>
</td></tr>
<tr>
<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
</th></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
</td>
<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=Q9BYX4">Hovergen</a>
</td></tr>
<tr>
<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;">
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Hausmaus
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=64135&rn=1">64135</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=71586&rn=1">71586</a></span>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="Ensembl" title="Ensembl">Ensembl</a>
</td>
<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000115267;db=core">ENSG00000115267</a></small></small></span>
</td>
<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000026896;db=core">ENSMUSG00000026896</a></small></small></span>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q9BYX4">Q9BYX4</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q8R5F7">Q8R5F7</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (mRNA)
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_022168">NM_022168</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001164477">NM_001164477</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (Protein)
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_071451">NP_071451</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001157949">NP_001157949</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="Genlocus" title="Genlocus">Genlocus</a>
</td>
<td><span class=""> <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human?db=hg38&position=chr2:162267079-162318703">Chr 2: 162.27 – 162.32 Mb</a> </span>
</td>
<td><span class=""> <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&position=chr2:62595798-62646255">Chr 2: 62.6 – 62.65 Mb</a> </span>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=64135">64135</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=71586">71586</a></span>
<p><span class="editoronly" style="display:none;"></span>
</p>
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>MDA5</b> (<span style="font-style:normal;font-weight:normal"><a href="Englische_Sprache" title="Englische Sprache">englisch</a></span> <span lang="en-Latn" style="font-style:italic"><i>melanoma differentiation-associated protein 5</i></span> ‚Melanom-Differenzierungsantigen 5‘) ist ein <a href="Resistenzfaktor" class="mw-redirect" title="Resistenzfaktor">Resistenzfaktor</a> in <a href="S%C3%A4ugetiere" title="Säugetiere">Säugetieren</a> gegen <a href="RNA-Viren" class="mw-redirect" title="RNA-Viren">RNA-Viren</a> mit doppelsträngigem <a href="Genom" title="Genom">Genom</a> aus der Familie der RIG-I-like Receptors (RLR).
</p>
<div class="mw-heading mw-heading2"><h2 id="Eigenschaften">Eigenschaften</h2></div>
<p>Das <i>MDA5</i> ist ein <a href="Pattern-Recognition_Receptor" class="mw-redirect" title="Pattern-Recognition Receptor">Pattern-Recognition Receptor</a> für ds<a href="RNA" class="mw-redirect" title="RNA">RNA</a> im <a href="Zytosol" class="mw-redirect" title="Zytosol">Zytosol</a>. Das Protein <i>MDA5</i> besteht aus drei funktionellen Teilen. Die Bindung von dsRNA an den <a href="C-Terminus" title="C-Terminus"><i>C</i>-Terminus</a> aktiviert eine <a href="Helikase" class="mw-redirect" title="Helikase">Helikase</a>-Funktion in der Mitte des <i>MDA5</i>, die der Abwehr von dsRNA-enthaltenden Viren dient. Nach Bindung von dsRNA erfolgt über die im MDA5 enthaltene <a href="N-Terminus" title="N-Terminus"><i>N</i>-terminale</a> CARD-<a href="Proteindom%C3%A4ne" title="Proteindomäne">Proteindomäne</a> (<i>caspase-recruitment domain</i>) eine Induktion von <a href="Interferon" class="mw-redirect" title="Interferon">Interferonen</a> des Typs 1 über das Protein <i>IPS-1</i> (synonym <i>VISA</i>, <i>Cardif</i>).<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Die stärkste Aktivierung von MDA5 erfolgt durch dsRNA von über 2000 <a href="Basenpaar" title="Basenpaar">Basenpaaren</a> Länge.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Der <a href="RIG-I" title="RIG-I">RIG-I</a>-artige Rezeptor <i>LGP2</i> ist an der antiviralen Funktion des <i>MDA5</i> beteiligt.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Durch die Bindung an dsRNA bilden <i>MDA5</i>-Proteine eine faserartige Struktur.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p><p>Das Gen <i>IFIH1</i> codiert das Protein <i>MDA5</i>. Das Singleton-Merten-Syndrom wird durch Mutationen von <i>IFIH1</i> verursacht und Mutationen an <i>IFIH1</i> sind an der Entstehung des <a href="Aicardi-Gouti%C3%A8res-Syndrom" title="Aicardi-Goutières-Syndrom">Aicardi-Goutières-Syndroms</a> beteiligt.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Eine Beteiligung von Mutationen des MDA5 wird bei <a href="Lupus_erythematodes" title="Lupus erythematodes">Lupus erythematodes</a> vermutet.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>
<ul><li>D. Luo: <i>Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors.</i> In: <i>RNA biology.</i> Band 11, Nummer 1, 2014, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221555-8584%22&key=cql">1555-8584</a></span></span>, S. 25–32, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.4161/rna.27717">10.4161/rna.27717</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/24457940?dopt=Abstract">PMID 24457940</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929420/">PMC 3929420</a> (freier Volltext).</li>
<li>D. C. Rawling, A. M. Pyle: <i>Parts, assembly and operation of the RIG-I family of motors.</i> In: <i>Current opinion in structural biology.</i> Band 25, April 2014, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221879-033X%22&key=cql">1879-033X</a></span></span>, S. 25–33, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.sbi.2013.11.011">10.1016/j.sbi.2013.11.011</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/24878341?dopt=Abstract">PMID 24878341</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070197/">PMC 4070197</a> (freier Volltext).</li>
<li>M. Yoneyama, K. Onomoto, M. Jogi, T. Akaboshi, T. Fujita: <i>Viral RNA detection by RIG-I-like receptors.</i> In: <i>Current opinion in immunology.</i> Band 32C, Februar 2015, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221879-0372%22&key=cql">1879-0372</a></span></span>, S. 48–53, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.coi.2014.12.012">10.1016/j.coi.2014.12.012</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/25594890?dopt=Abstract">PMID 25594890</a>.</li>
<li>E. Dixit, J. C. Kagan: <i>Intracellular pathogen detection by RIG-I-like receptors.</i> In: <i>Advances in immunology.</i> Band 117, 2013, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221557-8445%22&key=cql">1557-8445</a></span></span>, S. 99–125, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/B978-0-12-410524-9.00004-9">10.1016/B978-0-12-410524-9.00004-9</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/23611287?dopt=Abstract">PMID 23611287</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947775/">PMC 3947775</a> (freier Volltext).</li>
<li>K. R. Rodriguez, A. M. Bruns, C. M. Horvath: <i>MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction.</i> In: <i>Journal of virology.</i> Band 88, Nummer 15, August 2014, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221098-5514%22&key=cql">1098-5514</a></span></span>, S. 8194–8200, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1128/JVI.00640-14">10.1128/JVI.00640-14</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/24850739?dopt=Abstract">PMID 24850739</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135949/">PMC 4135949</a> (freier Volltext).</li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">O. Takeuchi, S. Akira: <i>MDA5/RIG-I and virus recognition.</i> In: <i>Current opinion in immunology.</i> Band 20, Nummer 1, Februar 2008, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220952-7915%22&key=cql">0952-7915</a></span></span>, S. 17–22, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.coi.2008.01.002">10.1016/j.coi.2008.01.002</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18272355?dopt=Abstract">PMID 18272355</a>.</span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">A. Szabo, E. Rajnavolgyi: <i>Collaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responses.</i> In: <i>American journal of clinical and experimental immunology.</i> Band 2, Nummer 3, 2013, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%222164-7712%22&key=cql">2164-7712</a></span></span>, S. 195–207, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/24179728?dopt=Abstract">PMID 24179728</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808934/">PMC 3808934</a> (freier Volltext).</span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">H. Kato, O. Takeuchi, E. Mikamo-Satoh, R. Hirai, T. Kawai, K. Matsushita, A. Hiiragi, T. S. Dermody, T. Fujita, S. Akira: <i>Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.</i> In: <i>The Journal of experimental medicine.</i> Band 205, Nummer 7, Juli 2008, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221540-9538%22&key=cql">1540-9538</a></span></span>, S. 1601–1610, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1084/jem.20080091">10.1084/jem.20080091</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18591409?dopt=Abstract">PMID 18591409</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442638/">PMC 2442638</a> (freier Volltext).</span>
</li>
<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">T. Satoh, H. Kato, Y. Kumagai, M. Yoneyama, S. Sato, K. Matsushita, T. Tsujimura, T. Fujita, S. Akira, O. Takeuchi: <i>LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.</i> In: <i><a href="Proceedings_of_the_National_Academy_of_Sciences" class="mw-redirect" title="Proceedings of the National Academy of Sciences">Proceedings of the National Academy of Sciences</a>.</i> Band 107, Nummer 4, Januar 2010, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221091-6490%22&key=cql">1091-6490</a></span></span>, S. 1512–1517, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1073/pnas.0912986107">10.1073/pnas.0912986107</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/20080593?dopt=Abstract">PMID 20080593</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824407/">PMC 2824407</a> (freier Volltext).</span>
</li>
<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text">Y. Del Toro Duany, B. Wu, S. Hur: <i>MDA5-filament, dynamics and disease.</i> In: <i>Current opinion in virology.</i> [elektronische Veröffentlichung vor dem Druck] Februar 2015, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221879-6265%22&key=cql">1879-6265</a></span></span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.coviro.2015.01.011">10.1016/j.coviro.2015.01.011</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/25676875?dopt=Abstract">PMID 25676875</a>.</span>
</li>
<li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text">F. Rutsch, M. MacDougall, C. Lu, I. Buers, O. Mamaeva, Y. Nitschke, G. I. Rice, H. Erlandsen, H. G. Kehl, H. Thiele, P. Nürnberg, W. Höhne, Y. J. Crow, A. Feigenbaum, R. C. Hennekam: <i>A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome.</i> In: <i><a href="American_Journal_of_Human_Genetics" class="mw-redirect" title="American Journal of Human Genetics">American Journal of Human Genetics</a>.</i> Band 96, Nummer 2, Februar 2015, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221537-6605%22&key=cql">1537-6605</a></span></span>, S. 275–282, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.ajhg.2014.12.014">10.1016/j.ajhg.2014.12.014</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/25620204?dopt=Abstract">PMID 25620204</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320263/">PMC 4320263</a> (freier Volltext).</span>
</li>
<li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text">L. Oliveira, N. A. Sinicato, M. Postal, S. Appenzeller, T. B. Niewold: <i>Dysregulation of antiviral helicase pathways in systemic lupus erythematosus.</i> In: <i>Frontiers in genetics.</i> Band 5, 2014, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221664-8021%22&key=cql">1664-8021</a></span></span>, S. 418, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.3389/fgene.2014.00418">10.3389/fgene.2014.00418</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/25505487?dopt=Abstract">PMID 25505487</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243696/">PMC 4243696</a> (freier Volltext).</span>
</li>
</ol></div><!--htdig_noindex--><div><div class="zim-footer">
Dieser Artikel wurde von <a class="external text" title="Zuletzt bearbeitet am 2022-08-14" href="https://de.wikipedia.org/wiki/?title=MDA5&oldid=225332809">Wikipedia</a> herausgegeben. Der Text ist unter <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.de">Creative Commons Attribution-Share Alike 4.0</a> verfügbar, sofern nicht anders angegeben. Für die Mediendateien können zusätzliche Bedingungen gelten.
</div>
</div><!--/htdig_noindex--></div>
</div>
</main>
</div>
</div>
</div>
<script src="./_webp_/webpHandler.js"></script>
</body></html>